The singer has announced plans to quit show business and turn his back on "celebrity narcissism" following his son's battle with cancer.
He has said he no longer had a desire for fame and would be stepping away from the limelight after releasing what may be his final album.
Buble's emotional "last interview" comes after he put his career on hold after his son Noah was diagnosed with liver cancer two years ago.
The five-year-old, one of three children with his Argentinian model wife Luisana Lopilato, is now in remission.
The Canadian performer, 43, spoke about the impact of his son's illness on his family.
He told the Daily Mail's Weekend Magazine: "My whole being's changed. My perception of life. I don't know if I can even get through this conversation without crying.
"And I've never lost control of my emotions in public."
Buble, who has sold 75 million records and won four Grammys, said his son's diagnosis helped him see how he had become fixated on his own success.
But the musician soon found himself recording again about a year ago and is set to release his new album, Love, next month.
He has also teamed up with chat show host James Corden for a special edition of Carpool Karaoke for Stand Up To Cancer.
Buble hinted his new album may be his last, adding: "I'm retiring from the business... I've made the perfect record and now I can leave at the very top."