The legendary DJ and producer – best known for hit Children – passed away after suffering a mystery illness, DJ Mag Italia reports.
Longtime friend Joe T Vannelli said: "The tragic news of the death of a very talented artist of our time, makes me incredulous and upset.
"I will miss the fights, brawls, criticism, judgements but especially your talent in finding sounds and melodies unparalleled."
Miles is thought to have been in dance music capital Ibiza, Spain, where he hosted a radio show, when he died.
The Italian's iconic hit Children made number one in 12 countries after its release in 1995.
It also reached the top five in "every European country with a singles chart".
Radio 1's Pete Tong brought the song to fame in the UK after playing it as his Essential Tune of the Week for three weeks straight in 1996.
Miles won the Brit Award for Best International Male Newcomer in 1997 off the back of the song's fame.
Children has remained a club classic for DJs across the globe.
He released six studio albums, with his 1996 record Dreamland marking his biggest commerical success. It reached the Top 10 in seven countries.
Miles - real name Robert Concinca - spent the rest of his career creating experimental music and launched OpenLab, a Balearic radio station.
He hosted a live set every Sunday at 11pm on the station, titled Hypnotronik.
Fans worldwide are flooding soundcloud recordings of his sets with emotional tributes.
DJs and dance legends led the tributes as they poured in online this morning.
Pete Tong said: "Sad to hear Robert Miles passing r.i.p thanks for the music #deconstruction#classichouse."
Armin Van Buuren said: "Really in shock to hear the news of the passing of Robert Miles... R.I.P."
Producer Chris Lake added: "RIP Robert Miles. 'Children' was the first dance song I fell in love with in 1996. I will forever be grateful for your music, thank you."
DJ Adaro wrote: "RIP dreamhouse legend Robert Miles, way too young!"