He is best known for appearing on Never Mind The Buzzcocks.
In his final tweet, sent on October 8, he wrote simply: "In hospital."
Ross Noble wrote: "Just awful news about Sean Hughes.he was very nice to me when I was starting out in comedy.
"A sad loss."
Alongside his role in Never Mind The Buzzcocks, he appeared in the ITV series The Last Detective, and played Pat, a love interest of Eileen Grimshaw, in Coronation Street.
Early on in his career, we won the prestigious Perrier Comedy Award for his A One Night Stand with Sean Hughes show.
He also had a small role in the 1991 film The Commitments.