33 people work for the company in the town.
Marks & Spencer has announced it is planning to close its Keighley store in the Airedale Shopping Centre.
The proposal is part of M&S's programme to close eight shops, which will impact 468 jobs. 33 people work for the company in Keighley.
Andrew Crooks, Head of Region for Yorkshire, said: "Proposing to close the Keighley store has been a difficult but necessary decision. Over the coming weeks we'll be talking to each colleague individually about what is right for them and we'll update customers and the community as soon as we can."
Sacha Berendji, Director of Retail at Marks & Spencer, said: "We're committed to transforming M&S for our customers, colleagues and shareholders. Stores will always be an integral part of our customer experience, alongside M&S.com, but we have to ensure we have the right offer in the right locations.
"We don't want any colleagues to leave M&S and we will work with each colleague individually on what is best for them as we endeavour to give everyone a role. However, we accept in some cases we may have to consider redundancy.
"We believe these changes are vital for the future of M&S and we will continue to accelerate the programme, taking tough but necessary decisions, as we focus on making M&S special."
M&S currently has 1,025 stores - 302 Clothing, Home and Food, 684 Food-only and 39 outlets.