The group have handed in their petition to Downing Street and are visiting the office of Health Secretary Jeremy Hunt.
The group fighting to stop the closure of Huddersfield's A&E department are in London today.
A coach load of Hands Off HRI protesters travelled down this morning to the capital.
It's all part of the campaign which was set up at the start of the year in the wake of plans to downgrade Huddersfield Royal Infirmary.
The proposals would see emergency care sent to Calderdale Royal Hospital in Halifax instead.
The group have handed in their petition- which has received 135 thousand signatures- to Downing Street, and are now heading to the Department of Health to protest in a static rally outside with other groups fighting similar fights are their local hospitals.
Helen Robinson from Golcar is part of the group Hands Off HRI. She told Pulse 1 & Pulse 2: "The more that we get out there, the more that we get into their faces, the more they are going to listen. That is what we're hoping.
"Aneurin Bevan started the NHS many years ago and I am sure he would be turning in his grave if he saw what was happening now."
- Hands Off HRI in Trafalgar Square
- Campaigners leaving for London this morning
- Front shot of campaigners with #HandsOffHRI banner
- Protest outside Number 10 Downing Street
- Campaigners at Trafalgar Square
- Side shot of campaigners group with #HandsOffHRI banner